分子认知实验室Molecular Cognition Lab 研究GABA抑制性突触的发育、调控与疾病机制Development, modulation, and disease mechanisms of GABAergic inhibitory synapses

发表论文Publications （共58篇，2026年10月更新；Lu W 加粗；* 为通讯作者；† 为共同第一作者）(58 papers, updated Oct 2026; Lu W in bold; * corresponding author; † co-first authors)

2026

  • Hong E, Reyes Mendez M, Guissart C, Zaafrane-Khachnaoui K, Kapoor A, Brzdąk P, Badger JD 2nd, Lu W, Roche KW. (2026). Pathogenic NLGN4X variants reveal dual roles in synaptic connectivity and cortical development. Translational Psychiatry (online 19 Sep 2026).

2025

  • Hachem LD, Moradi Chameh H, Balbinot G, Mothe AJ, Pacis A, Geng Li RT, Valiante TA, Lu W, Tator CH, Fehlings MG. (2025). Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery. Nature Neuroscience 28(10), 2054-2066.
  • Duan JJ, Jiang B, Yin W, Lin Y, Yan GM, Lu W*. (2025). Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memory. EMBO Reports 26(18), 4456-4476.
  • Pandey S, Ostergren S, Li J, Peng S, Wang G, Tian Q, Dong L, Lu W*. (2025). A critical role of neuroligin 2 C-terminus in OCD and social behavior. Journal of Neuroscience 45(19).
  • Lehr AW, Nguyen TA, Han W, Hong E, Badger JD 2nd, Lu W, Roche KW. (2025). Phosphorylation of NLGN4X regulates spinogenesis and synaptic function. eNeuro 12(3).

2024

  • Wang G, Peng S, Reyes Mendez M, Keramidas A, Castellano D, Wu K, Han W, Tian Q, Dong L, Li Y, Lu W*. (2024). The TMEM132B-GABA(A) receptor complex controls alcohol actions in the brain. Cell 187(23), 6649-6668.
  • Pandey S, Han W, Li J, Shepard R, Wu K, Castellano D, Tian Q, Dong L, Li Y, Lu W*. (2024). Reversing anxiety by targeting a stress-responsive signaling pathway. Proceedings of the National Academy of Sciences USA 121(31), e2400078121.
  • Efthymiou S, Han W, Ilyas M, Li J, Yu Y, Scala M, et al., Lu W, Houlden H. (2024). Human mutations in SLITRK3 implicated in GABAergic synapse development in mice. Frontiers in Molecular Neuroscience 17, 1222935.
  • Zhu S, Shen Z, Wu X, Han W, Jia B, Lu W, Zhang M. (2024). Demixing is a default process for biological condensates formed via phase separation. Science 384(6698), 920-928.
  • Vieira MM, Peng S, Won S, Hong E, Inati SK, Thurm A, Thiam AH, Kim S, Myers SJ, Badger JD 2nd, Traynelis SF, Lu W, Roche KW. (2024). A frameshift variant of GluN2A identified in an epilepsy patient results in NMDA receptor mistargeting. Journal of Neuroscience 44(4).
  • Ernst M, Lu W, Mattei C. (2024). Editorial: The GABAA receptor: a target of pharmacologically active molecules. Frontiers in Pharmacology 15, 1440937.

2023

  • Wu K, Lu W*. (2023). GABAergic synaptic transmission and plasticity oscillate across sleep and wake. Neural Regeneration Research 18(12), 2647-2648.
  • Jeong J, Han W, Hong E, Pandey S, Li Y, Lu W, Roche KW. (2023). Regulation of NLGN3 and the synaptic Rho-GEF signaling pathway by CDK5. Journal of Neuroscience 43(44), 7264-7275.
  • Luo J, Chen Z, Castellano D, Bao B, Han W, Li J, Kim G, An D, Lu W, Wu C. (2023). Lipids regulate peripheral serotonin release via gut CD1d. Immunity 56(7), 1533-1547.

2022

  • Wu K, Han W, Lu W*. (2022). Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity. PLOS Biology 20(11), e3001812.
  • Castellano D, Wu K, Keramidas A, Lu W*. (2022). Shisa7-dependent regulation of GABA(A) receptor single-channel gating kinetics. Journal of Neuroscience 42(47), 8758-8766.
  • Wu K†, Shepard RD†, Castellano D, Han W, Tian Q, Dong L, Lu W*. (2022). Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors. Neuropsychopharmacology 47(12), 2160-2170.

2021

  • Wu K, Castellano D, Tian Q, Lu W*. (2021). Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes. Cell Reports 37(6), 109960.
  • Wang G, Yin W, Shin H, Tian Q, Lu W*, Hou SX. (2021). Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nature Aging 1(11), 1024-1037.
  • Wu K, Han W, Tian Q, Li Y, Lu W*. (2021). Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Reports 34(12), 108899.
  • Han W†, Shepard RD†, Lu W*. (2021). Regulation of GABA(A)Rs by transmembrane accessory proteins. Trends in Neurosciences 44(2), 152-165.
  • Castellano D†, Shepard RD†, Lu W*. (2021). Looking for novelty in an "old" receptor: recent advances toward our understanding of GABA(A)Rs and their implications in receptor pharmacology. Frontiers in Neuroscience 14, 616298.

2020

  • Vieira MM, Nguyen TA, Wu K, Badger JD 2nd, Collins BM, Anggono V, Lu W, Roche KW. (2020). An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking. Cell Reports 32(9), 108104.
  • Pandey S, Ramsakha N, Sharma R, Gulia R, Ojha P, Lu W, Bhattacharyya S. (2020). The post-synaptic scaffolding protein tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors. Journal of Biological Chemistry 295(25), 8575-8588.
  • Nguyen TA, Wu K, Pandey S, Lehr AW, Li Y, Bemben MA, Badger JD 2nd, Lauzon JL, Wang T, Zaghloul KA, Thurm A, Jain M, Lu W, Roche KW. (2020). A cluster of autism-associated variants on X-linked NLGN4X functionally resemble NLGN4Y. Neuron 106(5), 759-768.
  • Luo L, Ambrozkiewicz MC, Benseler F, et al., Lu W, Kawabe H, Craig AM. (2020). Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors. Neuron 106(1), 37-65.

2019

  • Han W, Li J†, Pelkey KA†, Pandey S, Chen X, Wang YX, Wu K, Ge L, Li T, Castellano D, Liu C, Wu LG, Petralia RS, Lynch JW, McBain CJ, Lu W*. (2019). Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions. Science 366(6462), 246-250.
  • Duan J, Pandey S, Li T, Castellano D, Gu X, Li J, Tian Q, Lu W*. (2019). Genetic deletion of GABA(A) receptors reveals distinct requirements of neurotransmitter receptors for GABAergic and glutamatergic synapse development. Frontiers in Cellular Neuroscience 13, 217.
  • Li J, Han W, Wu K, Li YPD, Liu Q, Lu W*. (2019). A conserved tyrosine residue in Slitrk3 carboxyl-terminus is critical for GABAergic synapse development. Frontiers in Molecular Neuroscience 12, 213.
  • Jeong J, Pandey S, Li Y, Badger JD 2nd, Lu W, Roche KW. (2019). PSD-95 binding dynamically regulates NLGN1 trafficking and function. Proceedings of the National Academy of Sciences USA 116(24), 12035-12044.

2018

  • Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E, Bao H, Lu W, Toni N, Song J. (2018). Mossy cells control adult neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways. Neuron 99(3), 493-510.
  • Gu X, Lu W*. (2018). Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters 668, 147-153.
  • Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. (2018). Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. Journal of Clinical Investigation 128(2), 774-788.
  • Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. (2018). Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry 23(5), 1213-1225.
  • Su T, Lu Y, Geng Y, Lu W, Chen Y. (2018). How could N-methyl-D-aspartate receptor antagonists lead to excitation instead of inhibition? Brain Science Advances 4(2), 73-98.

2017

  • Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W*. (2017). Molecular dissection of neuroligin 2 and Slitrk3 reveals an essential framework for GABAergic synapse development. Neuron 96(4), 808-826.
  • Han W†, Wang H†, Li J, Zhang S, Lu W*. (2017). Ferric chelate reductase 1 like protein (FRRS1L) associates with dynein vesicles and regulates glutamatergic synaptic transmission. Frontiers in Molecular Neuroscience 10, 402.
  • Liu S, Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD 2nd, Lu W, Traynelis SF, Roche KW. (2017). A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density. Journal of Neuroscience 37(15), 4093-4102.
  • Lu W*, Bromley-Coolidge S, Li J. (2017). Regulation of GABAergic synapse development by postsynaptic membrane proteins. Brain Research Bulletin 129, 30-42.
  • Lu W*, Chen Y. (2017). Development of fast neurotransmitter synapses: general principle and recent progress. Brain Research Bulletin 129, 1-2.
  • Mao X, Gu X, Lu W*. (2017). GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons. Journal of Neurophysiology 117(1), 28-35.

2016

  • Gu X†, Mao X†, Lussier MP†, Hutchison MA†, Zhou L, Hamra FK, Roche KW, Lu W*. (2016). GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications 7, 10873.
  • Gu X, Zhou L, Lu W*. (2016). An NMDA receptor-dependent mechanism underlies inhibitory synapse development. Cell Reports 14(3), 471-478.

2015

  • Lomash RM, Gu X, Youle RJ, Lu W, Roche KW. (2015). Neurolastin, a dynamin family GTPase, regulates excitatory synapses and spine density. Cell Reports 12(5), 743-751.

2014

  • Lu W, Khatri L, Ziff EB. (2014). Trafficking of AMPA receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex containing CaMKII and PICK1 and by release of Ca2+ from internal stores. Journal of Biological Chemistry 289(27), 19218-19230.
  • Lussier MP, Gu X, Lu W, Roche KW. (2014). Casein kinase 2 phosphorylates GluA1 and regulates its surface expression. European Journal of Neuroscience 39(7), 1148-1158.

2013

  • Lu W, Bushong EA, Shih TP, Ellisman MH, Nicoll RA. (2013). The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function. Neuron 78(3), 433-439.
  • Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013). LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature 493(7433), 495-500.

2012

  • Lu W*, Roche KW. (2012). Posttranslational regulation of AMPA receptor trafficking and function. Current Opinion in Neurobiology 22(3), 470-479.

2011

  • Lu W, Gray JA, Granger AJ, During MJ, Nicoll RA. (2011). Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit. Journal of Neurophysiology 105(2), 923-928.
  • Granger AJ, Gray JA, Lu W, Nicoll RA. (2011). Genetic analysis of neuronal ionotropic glutamate receptor subunits. Journal of Physiology 589(Pt 17), 4095-4101.

2010

  • Lu W, Isozaki K, Roche KW, Nicoll RA. (2010). Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. Proceedings of the National Academy of Sciences USA 107(51), 22266-22271.
  • Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. (2010). Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65(1), 66-79.

2009

  • Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009). Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron 62(2), 254-268.
  • Shi Y, Lu W, Milstein AD, Nicoll RA. (2009). The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type. Neuron 62(5), 633-640.

2007

  • Silverman JB, Restituito S, Lu W, Lee-Edwards L, Khatri L, Ziff EB. (2007). Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein-AMPA receptor-binding protein complexes. Journal of Neuroscience 27(32), 8505-8516.
  • Morishita W, Lu W, Smith GB, Nicoll RA, Bear MF, Malenka RC. (2007). Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology 52(1), 71-76.

2005

  • Lu W, Ziff EB. (2005). PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Neuron 47(3), 407-421.